Nasal Administration For Optimized Lamotrigine Loaded Nanoliposomes And Chitosan Coating Nanoliposomes: Ex Vivo and In Vivo Evaluation study for Goat


  • Deepika Gupta*, Satyaendra K. Shrivastava and Rajeev Kumar Malviya


Lamotrigine Nanoliposomes, Nasal Administration, Release mechanism, In Vivo and Ex Vivo study.


The objective of this study was to analysis the amount of LTG released from the nanoliposomes was determined by Ex-Vivo Preparation of goat nasal mucosa: Fresh goat nose was collected from local slaughter house after animal sacrifice. Full nasal mucosa was peeled off carefully from lateral wall of nose by a longitudinal incision using    a  scalpel. The isolated nasal mucosa was washed 2-3 times with distilled water, kept in 10% v/v formalin solution and stored in the freezer at minus 20ºC to later perform permeation study, confocal imaging and nasal toxicity study.

The release kinetics study of Opt-LTG-NLs and Chit-Opt-NLs were determined by the calculative result of ex-vivo studies. The obtained data were fitted in various kinetic models; such as zero order, first order and Higuchi‘s model. In which zero order follows cumulative percent of drug released in respect of time, while first order follows log cumulative percentage of drug release versus time. Higuchi‘s model follows cumulative percent drug released in respect of square root of time. In Korsmeyer and Peppas model, diffusion will be Fickian if n= 0.5 and non-Fickian if 0.5 <