Formulation Design and Evaluation of Nasal toxicity study: Lamotrigine encapsulated intra-nasal nanoliposome formulation for Huntington‘s disease (HD):

Abstract

Introduction: The purpose of this study was to develop lamotrigine nanoliposomes (LTG-NLs) for the treatment in chorea.

Material and Methods: The formulation was prepared using thin film dehydration– rehydration method using the phospholipon 90 G, cholesterol and tween 80 as main ingredients. The nanoliposomes were optimized by plucket burman design (PBD) and response surface methodology (RSM) optimization techniques. The optimized LTGNLopt was further characterized for surface morphology, in-vitro release, stability study, confocal laser scanning microscopic (CLSM) study and naso toxicity study

Result and Discussion: The results showed that LTGNLopt shown nano size with high entrapment and drug release. The ex-vivo permeation study and confocal laser microscopy study confirmed the enhancement in permeation across the goat nasal mucosa.

Conclusion: From the study, it was concluded that the independent variables used to optimize the NLs shown significant effect on the dependent variables and consider effective lipid carrier system for intranasal delivery.