Metabolic Syndrome- An Evaluation And Interrelations Of Metabolic Risk Markers In Type 2 Diabetes Mellitus Patients

Authors

  • Vijayakumar A*, Maheshkumar V P and Manisenthilkumar K T

Keywords:

Metabolic syndrome, life style modifications, HbA1c, abdominal obesity.

Abstract

Objectives

Introduction: Metabolic syndrome is a cluster of medical conditions that include abdominal obesity, high blood pressure, high blood sugar and abnormal cholesterol levels. It is established that those with metabolic syndrome have a five times higher risk of cardiovascular disease and diabetes. Metabolic disease increases the risk of morbidity and mortality. Objectives: Purpose of this study was to examine the changes in weight, BMI, glycemic and cardiometabolic parameters among the groups, and to compare the effect of lifestyle modification with lorcaserin and without lifestyle intervention. Results: We included 350 patients in analysis the results showed a significant decrease in weight between visit 1 and visit 3, indicating that the long-term outcome on weight was improving. Although there was no significant difference in BMI among the three measurements, the mean BMI of females was significantly higher than that of males. Fasting blood sugar levels, HbA1C, and triglycerides also decreased over time, while HDL levels increased. The study suggests that lorcaserin can have positive effects on weight loss and improvements in metabolic syndrome markers. The treatment with Lorcaserin 10 mg twice daily with SGLT2 inhibitors had a positive effect on blood pressure and lipid levels but did not significantly affect weight and blood sugar levels. The results highlight the importance of lifestyle modifications in reducing blood sugar levels. 

Published

2023-04-07

Issue

Section

Articles