Important Operation and Nursing Application Value of a New Heterocyclic Compound on Postoperative Infection

Abstract

The new heterocycles compound 4-aminopyridine-3-sulfonamide (1), designed using 4-aminopyridine-3-sulfonic acid (2) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, 1H NMR, and single crystal X-ray crystallography. Its application values on postoperative infection
after joint replacement of colleagues was evaluated and the related mechanism was explored. The ELISA assay was
conducted to measure the content of inflammatory cytokines released into the joint cavity. Additionally, the NF-κB
signaling pathway activation in the joint tissue was measured as well.