Vasculoprotective Effects of Vitexin on Triton Wr1339 Induced Oxidative Stress in Rats

Abstract

Atherosclerosis is pathologically formation of plaques; occur preferentially in coronary arteries,
where shear stress is oscillatory. Triton WR1339 causes decrease in shear stress leading to oxidative stress and
endothelial wall damage. The objective was to evaluate the protective effect of vitexin in Triton Wr1339 induced
vascular complications in rats. Sprague Dawley rats were used for the experiment. All groups were given Triton
WR-1339 for 7 days. The blood serum was used to estimate the levels of TBARS, catalase, total cholesterol,
triglyceride, LDL, and HDL using assay kits. In present study, we evaluated the pharmacological activities of
Vitexin (PubChem CID: 5,280,441) (C21H20O10) in Triton WR 1339 induced atherosclerosis. In Triton induced
atherosclerosis, results demonstrated that there was significantly increased in serum lipid levels, MDA levels
along with increased levels of liver enzymes except decreased in HDL and catalase levels. While treatment with
vitexin observed the protective effect of these drugs on above variables. Vitexin markedly reduced TC, TG and
LDL-C levels, however raised HDL-C levels. Concentrations of CRP, IL-1β, IL-8 and IL-18 have decreased.
AECP lowered the ET and TXB2 levels but increased the 6-keto-PGF1α levels. Histopathological analysis has
demonstrated that vitexin prevented pathological improvements in the arteries of AS rats and decreased IMT