Phytochemical Studies and Cytotoxic Potential with In-vitro Scavenging Activity of Calotropis gigantea linn latex


  • Negi Divya*, Bisht A.S., Singh Arun Kumar, Upreti Arpita , Kandpal Shikha, Rautela Jaya


Calotropis gigantea Linn, Pharmacological studies.


Calotropis gigantea Linn species is well-known restorative herb and it is commonly known as milk weed, utilized in Indian system of medication. The plant exudates of Calotropis gigantea showed the excellent cytotoxic and antioxidant activity.The phyto-chemical investigation of plant exudates were carried out and results showed the presence of alkaloids, cardiac glycosides, flavonoids, steroids, tannins, triterpenoids, carbohydrates and saponins.The Antioxidant activity addresses a huge capacity to help human, against infections and chronic diseases.The antioxidant activity was performed by DPPH (1, 1-Diphenyl-2-picrylhydrazyl) free radical scavenging activity method. Further the cytotoxic activity in term of LC50 (lethality concentration) was evaluated by Brine Shrimp Lethality Assay (BSLA). The results (IC50 and LC50) obtained from the above study was compared with the standard and found that the plant exudates have excellent antioxidant and cyotoxic activity mothers.