Effect Of Psyllium Husk In The Formulation Development And Evaluation Of Metoprolol Succinate Floating Microspheres By Modified Emulsion Solvent Diffusion Method

Abstract

A sustained release system for Metoprolol Succinate designed to increase its residence time in the stomach without contact with the Microspheres was achieved through the preparation of floating Microspheres by the Modified Emulsion solvent Diffusion method. In the present study attempt has been made to develop sustained released drug delivery system by formulating the floating Microspheres of Metoprolol Succinate using psyllium husk powder as a natural polymer which is biodegradable, biocompatible, nontoxic, economically cheap cost, devoid of adverse and side effects and easily availability. Metoprolol Succinate chemically 1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol succinate  used as an Anti-hypertensive agent.  The 12 batches of floating Microspheres (MF1 to MF12) were formulated by Modified Emulsion solvent Diffusion method using different ratio of polymers like Psyllium husk power, HPMC K4M and Carbopal.  The formulated Microspheres were evaluated by means of different parameters like shape and density of Microsphere, drug content uniformity, Invitro buoyancy, swelling Index, Invitro dissolution studies.  The formulation MF6 has better sustained release  when compared other formulations, hence we conclude that the combination of Psyllium husk powder, HPMC K4M  shows better Gastric retention time which sustains the release of the dosage form.