Synergistic effects of ethyl acetate extract of leaves of Annona muricata Linn, and Curcumin for oral anti-cancer activity
People are attracted to medicinal plants and their unique formulations that are obtained from a variety of natural sources to treat cancer. Annona muricata, also referred to as Graviola, and curcumin have been shown to have anti-cancer properties. Nevertheless, no research has been done on the combined effects of these two possible phytoextracts/compounds. The purpose of our study is to determine whether curcumin and an extract from Annona muricata Linn produce beneficial synergistic effects in oral cancer cell lines. Curcumin and Annona muricata leaf extract both shown a synergistic inhibitory effect against the SCC-25 cell line in an in vitro evaluation (IC50 = 20 g/ml). Also, we prepared a herbal gel and examined its impact on the SCC-25 cell line. We discovered that the formulation containing 0.6% curcumin and 0.6% ethyl acetate extract from Graviola leaves had an optimum activity and produced synergistic effects.