The Molecular Mechanism of the Effect of Carvacrol on Desflurane Inhalation-Induced Liver Damage in Rats

Abstract

The metabolite of desflurane has been linked to hepatotoxicity. Carvacrol possesses antioxidant,
antibacterial, antifungal, anticancer, anti-inflammatory, and spasmolytic properties, according to research.
Our goal is to demonstrate that carvacrol protects rats’ livers against repeated doses of desflurane. Healthy
(HG), desflurane (DS), and carvacrol + desflurane treatment (CDS) groups were formed from 18 albino male
Wistar rats. A single dosage of carvacrol and 6% desflurane was given for 2 h on the 0th and 8th days. In the
CDS group, the ALT and AST, MDA, TOS, NF-κB, TNF-α IL1 β levels were lower compared to the DS group
(p < 0.001). The tGSH,TAS levels were found to be higher in the CDS group compared to the DS group (p <
0.001). It was determined that the mean degeneration level, Kupffer cell activation and PMNL infiltration
were found to be lower compared to the DS group (p < 0.05).We confirmed that carvacol can be used in the
treatment of desflurane-related liver injury.