In vivo Pharmacokinetic studies of Antiepileptic drug-loaded polymeric nanoparticles
Keywords:Epilepsy, Polymeric Nanoparticles, Sodium alginate, Chitosan, Pharmacokinetic evaluation.
Aim: The present study was aimed to prepare polymeric nanoparticles with an anti-epileptic drug, Lomotrigine and to enhance the bioavailability of lamotrigine by controlling the rate of drug release by polymeric nanoparticle. Method: The formulations were optimized by using Expert software design. The formulation variables which could affect the preparation were identified and optimized to get the nanoparticles with average particle size and highest drug entrapment efficacy. Formulation variables like concentration of polymer, concentration of drug and stabilizer concentration were studied against the response variables particle size and drug entrapment efficacy. Based on the optimization results, the selected formulations were subjected for pharmacokinetic studies. The various parameters such as Cmax, Tmax, Half-life was done by means of KINETICA application. The statistical analysis of the studies shown that the drug loaded sodium alginate chitosan nanoparticles possessed considerable improved drug amount on brain compared with that of drug. Results & Conclusion: The results showed, formulation shows a significant increase in volume of distribution and average residency and reduction in the plasma clearance rate. This is due to controlled release of Lamotrigine from Chitosan alginate Nanoparticles.