An Observational Study To Compare The Effects Of Intrathecal 30 Mg Chloroprocaine And 30 Mg Chloroprocaine With 30 Mcg Clonidine As Adjuvant In Infraumbilical Surgeries
Keywords:Chloroprocaine, clonidine, perianal surgeries
Background: Intrathecal adjuvants like alpha-2 agonists, opioids are increasingly used with local anaesthetic for spinal anaesthesia for intensifying subarachnoid block and improving the hemodynamic stability.
Methods: In this prospective randomized controlled study, patients were randomly divided into two groups of 25 each, group CP receiving chloroprocaine 3.0 ml + 0.9% normal saline (0.2 ml) total 3.2 ml and group CPC receiving chloroprocaine 3.0 ml + 30 mcg clonidine (0.2 ml) total 3.2 ml.
Results: The onset of sensory blockade was faster in group CPC (4.35 + 0.32) than CP (5.09 + 0.26) minutes (p < 0.05). Onset of motor blockade was faster in group CPC (4.98 + 0.25) than CP (6.38 + 0.28) minutes (p < 0.05). Time to two segment regression was faster in group in CP (45.56 + 2.96) than CPC (80.76 + 3.64) minutes (p < 0.05). Duration of sensory blockade was prolonged in group CPC (107.4 + 5.96) than CP (59.68 + 3.10) minutes (p < 0.05). Duration of motor blockade was prolonged in group BM (92.12 + 5.06) than CP (50.4 + 2.48) minutes (p < 0.05). Time to rescue analgesia was prolonged in group CPC (125.6 + 6.52) than CP (82.2 + 3.48) minutes (p<0.05). Few cases of hypotension and bradycardia were noted in both groups.
Conclusion: We found enhancement in onset, duration of sensory and motor blockade, 2 segment regression time and time to rescue analgesia by adding clonidine to intrathecal chloroprocaine . But hemodynamic stability was hampered by chloroprocaine.