An Observational Study Of Two Different Doses Of Intravenous Clonidine For Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patients Undergoing General Anaesthesia

Abstract

Background : Clonidine, an alpha agonist, is an effective premedication for patients undergoing general anesthesia wherein significant hemodynamic stress response is seen. However the safe minimum effective dose of intravenous clonidine for attenuation of hemodynamic stress response to intubation is not yet determined.

Material and methods :

This prospective randomized controlled study was conducted on 50 adults of ASA grade I and II scheduled for elective surgeries undergoing general  anaesthesia. Patients were randomized to one of the two groups (n=25). Group C2 and C3 received  2ug/kg and 3ug/kg clonidine intravenously, in 100 ml Normal Saline respectively over 15 minutes,10 minutes prior to induction along with inj glycopyrrolate 0.004 mg/kg and inj tramadol 2 mg/kg intravenously. Hemodynamic variables (heart rate, systolic, diastolic, mean arterial pressure) were recorded at 1,3 5,10,15 minutes after intubation.

Results :

Clonidine 3 ug/kg attenuated the hemodynamic stress response to direct laryngoscopy and intubation undergoing general anaesthesia more effectively than 2ug/kg at all times of observation. (p<0.05). 

Conclusion :

We concluded that to limit hemodynamic stress responses during intubation, in general anesthesia 3 μg/kg intravenous Clonidine can safely &effectively be recommended as a premedicant 10minutes prior to the surgery.