Latin American Journal of Pharmacy : A Life Science Journal 2024-02-21T09:27:24+00:00 Latin American Journal of Pharmacy Open Journal Systems <div align="justify"><strong><em>Latin American Journal of Pharmacy</em> (formerly <em>Acta Farmacutica Bonaerense</em>) ISSN 0326 2383</strong> is the scientific journal of the College of Pharmacists of Buenos Aires Province, Argentina. The journal publishes research reports in the form of original articles or short communications on most aspects of pharmaceutical sciences, with strong emphasis on originality and scientific quality. More specifically, but not exclusively, the journal publishes mainly reports in medicinal chemistry, pharmacology, drug absorption and metabolism, pharmacokinetics and pharmacodynamics, pharmaceutical and biomedical analysis, drug delivery, pharmaceutical technology and biotechnology, pharmaceutical care, and clinical drug evaluation. Reviews or mini-reviews are not encouraged, but experimental articles are privileged. Articles reporting the isolation of secondary metabolites of plants will be only considered if biological and toxicological assays are included. In general, reports on biological activities of crude extracts are not considered for publication unless any bioactive compound is isolated and identified. Contributions reporting unexceptional and predictable bioactivity (for instance, antioxidant activity of extracts or antimicrobial activity of essential oils) are not normally considered for publication.<br /><br />Articles are indexed and abstracted in Chemical Abstracts Service, International Pharmaceutical Abstracts Service, BioScience Information Service (Biological Abstracts), Periodica (Index of Latin American Scientific Journals), International Pharmaceutical Technology &amp; Product Manufacture Abstracts, Referativnyi Zhurnal (Institut of Scientific Information, Russian Academy of Sciences), EMBASE/Excerpta Medica, LILACS (Latin American and Caribbean Health Sciences Literature) and LATINDEX. The journal was awarded in 1986 and 2000 with APTA-Antonio Rizzuto prize (scientific journals category) and in 2002 was qualified as scientifical journal level one (excellent) by the Argentine Center of Scientific and Technological and Information (CAICYT-.CONICET) within the LATINDEX Project, integrantes the Common Core of Argentinian Scientific Journals and has been proclaimed as a journal of provincial interest by the Honorable Deputy Chamber of Buenos Aires Province, Argentina.<br />From 2017, <em>Lat. Am. J. Pharm.</em> publishes twelve issues per year</div> Health Logistics Managements In Sub-Sahara Africa 2024-01-18T14:11:17+00:00 Catherine Armah and Emmanuel G.K. Duncan s@s.b <p>Health logistics management plays a crucial role in ensuring the effective and efficient delivery of healthcare services, especially in resource-constrained regions such as Sub-Saharan Africa (SSA). This abstract provides an overview of the challenges, strategies, and potential solutions related to health logistics management in SSA. Sub-Saharan Africa faces unique challenges in healthcare logistics, including inadequate infrastructure, limited resources, geographical barriers, and high disease burdens. These challenges contribute to difficulties in the procurement, distribution, and storage of essential medical supplies, leading to disruptions in healthcare delivery.</p> <p>To address these challenges, various strategies are being employed in SSA. This includes the adoption of technology for inventory management, the establishment of centralized procurement systems, and the improvement of transportation infrastructure. Collaborative efforts between governments, non-governmental organizations, and international partners are also being promoted to enhance the coordination of logistics activities. Despite these efforts, several barriers persist, including weak governance structures, corruption, and insufficient financial resources. Additionally, the impact of global health crises, such as the COVID-19 pandemic, has further underscored the need for resilient and responsive health logistics systems in SSA.</p> <p>This study suggests that a holistic approach to health logistics management in SSA should involve capacity building, policy reforms, and sustained investments in healthcare infrastructure. Strengthening regional and international collaborations can facilitate knowledge exchange and resource mobilization to overcome common challenges. In conclusion, effective health logistics management is integral to improving healthcare outcomes in Sub-Saharan Africa. By addressing the unique challenges and implementing comprehensive strategies, the region can enhance its ability to provide timely and quality healthcare services, ultimately contributing to improved public health outcomes.</p> <p>&nbsp;</p> 2024-01-18T00:00:00+00:00 Copyright (c) 2024 A Comprehensive Review of Disintegrants: Backbone of disintegration 2024-01-23T10:24:29+00:00 Monika Sharma, Amarjeet Singh1, Sonia Gupta, Suresh Kumar*, Sandeep Kumar and Ankur s@s.b <p>Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents, their categories, mechanisms of action, associated pros and cons. Furthermore, more emphasis is on natural superdisintegrants, those perform disintegration at fastest rate with limited side effects. So, they are in frequent use to create number of preparations like fast dissolving tablet, pulsatile and tablet dispersible tablet etc. Despite of various disintegrants, superdisintegrants co-processed form of them are thoroughly investigated along with novel techniques of production such as Melt Extrusion, Crystallization, Spray Drying, Solvent Evaporation, Granulation/ Agglomeration.</p> 2024-01-23T00:00:00+00:00 Copyright (c) 2024 A prospective randomized comparative clinical study to evaluate the safety and efficacy of polyherbal metabolite compounds in type 2 diabetes mellitus 2024-01-25T14:10:36+00:00 Nandakumar Kadanangode Narayanaswamy, Chinnaperumal Kamaraj, Meenakshisundari, Bhuvaneshwaran Mothishwaran, Rajappan Chandra Satish Kumar, Venkataraman Prabhu s@s.b <p>Background: In this current state, Type 2 Diabetes Mellitus (T2DM) is more prevalent in the population, and metformin is used as a first-line medication for treating it. There was up surge in the utilization of alternative therapies in the management of diabetes. Especially in diabetes, Herbal medicines are considered safe and reliable by majority of the population. Methods: Hence the present study is aimed to estimate the safety and efficacy of Poly Herbal Metabolite Compound(PHMC) capsules in adults with T2DM. In this study, 60 T2DM patients aged 18-60 years were randomly assigned to Groups A (30) receiving Metformin 500 mg twice a day after food and Group B (30) receiving Poly Herbal Metabolite Compound(PHMC) capsule 500 mg twice a day after food in a prospective, randomized and open-label clinical study. The in silico simulation study was performed to selected plants major compounds on target protein Insulin-like Growth Factor-1 (1K3A). Results: Primary end points are to assess the efficacy and adverse drug reactions of Poly Herbal Metabolite Compound(PHMC) capsules during the period of the study.&nbsp; Secondary end point is to assess the safety of Poly Herbal Metabolite Compound(PHMC) capsules. The investigational drug (Poly Herbal Metabolite Compound(PHMC)) is found to be safe and effective in the management of T2DM. Conclusions: The results show that, Poly Herbal Metabolite Compound(PHMC) capsule tends to act like a gold standard drug metformin. With the above results we concluded that Poly Herbal Metabolite Compound(PHMC) capsule would be one of the suitable alternative choice in T2DM patients who are not sensitive to other therapies.</p> 2024-01-25T00:00:00+00:00 Copyright (c) 2024 Synthesis and biological evaluation of Schiff bases from substituted 1,3, 4 Thiadiazole as multi-functional agents with antimicrobial and antioxidant activities 2024-01-26T08:16:43+00:00 Sajid Ajit Malak, Madhuri Satish Patil, Mohd. Mustakim Sahrif s@s.b <p>Schiff bases have gradually evolved into powerful biological agents because of their biological and medicinal properties. In this work, an efficient method is developed for the synthesis of Schiff bases from substituted 1,3,4 Thiadiazole. All the synthesized molecules were characterized using various spectral techniques including FTIR, 1HNMR,13CNMR, and Mass spectrometry.All the new synthesized compounds were then screened for their antimicrobial activity against three types of bacteria and three fungal strains, by application of the MIC assays. The antioxidant activities were also estimated and strongly correlated with the potential of BHT or butylated hydroxy toluene. All the synthesised compounds showed good antimicrobial activity at concentrations ranging between at 1–2.25 g/mL. The synthesised compounds also showed promising antioxidant activities, as compared with BHT, with 3b, 3d, and 3h showing appreciable antioxidant efficacy.</p> 2024-01-25T00:00:00+00:00 Copyright (c) 2024 Maximizing Intubation Comfort: The Benefits of Betamethasone Gel Application on Endotracheal tube 2024-01-29T06:57:37+00:00 Dr. Manjunath Kandiraju s@s.b <p>Background: Steroids like Betamethasone gel usually restricted for application and treatment of skin disorders, but it can also be helpful in preventing postoperative complications of intubation such as cough, sore throat, and hoarseness of voice.</p> <p>Methods and Results: Multiple case studies including prospective, randomized controlled studies are taken into consideration, various studies, analysed and concluded that Betamethasone gel is superior when compared to other jellies like lignocaine jelly, K Y jelly application on the endotracheal tube optimizes the intubating conditions with ease and prevents post-operative complications.</p> <p>Conclusion: The maximum benefits of Betamethasone gel outweigh the benefit -risk ratio and superior as compared to other jellies in the market.</p> <p>&nbsp;</p> 2024-01-29T00:00:00+00:00 Copyright (c) 2024 Development, In-Vitro Evaluation And In-Vivo Pharmacokinetic Study Of Buspirone Hcl Solid Lipid Nanoparticles 2024-02-01T13:08:35+00:00 Ramshetti Rajendra Prasad And Shayeda* s@s.b <p>Buspirone hydrochloride (BUS HCl) treats anxiety disorders and relieves symptoms, however its bioavailability is 4–10%. Solid lipid nanoparticles (SLNs) are commonly spherical with a 50 to 1000 nm diameter. The objective of the study to develop solid lipid nanoparticles and improve the oral bioavailability of buspirone HCl. Differential scanning calorimetry (DSC) studies showed no interactions between drugs and lipids. The SLNs were designed through a process of hot homogenization followed by ultrasonication. The prepared formulations were evaluated for size, zeta potential (ZP), Polydispersity Index (PDI), entrapment efficiency (EE), in-vitro drug release, and stability studies. Field emission scanning electron microscopy (FESEM) studies revealed that pure drug had irregular particles, whereas SLNs contained spherical-shaped and uniform-sized particles. Based upon the results, F3 formulation was optimized having size (163.1±5.2nm), PDI (0.163±0.007), and showed in-vitro release (76.44±1.4%) in 24hrs. The formulation (F3) significantly improved pharmacokinetic parameters such as Cmax, AUC0-t, and t1/2 and increased bioavailability by 2.3 folds that of coarse suspension.</p> 2024-02-01T00:00:00+00:00 Copyright (c) 2024 Histiocytic necrotizing lymphadenitis with autoimmune encephalitis in a child: a case report 2024-02-03T12:51:21+00:00 Yiyun Zhou, Sainan Shu* s@s.b <p>Backgrounds: Histiocytic necrotizing lymphadenitis (HNL) is a rare benign self-limiting inflammatory disease that mainly affects young adults, however, the exact pathogenesis is unknown. A 4-year-old child who was diagnosed with HNL combined with autoimmune encephalitis (AE) was admitted to our hospital. This study aimed to investigate the clinical characteristics, laboratory tests, imaging findings, and treatment outcomes of pediatric patients with HNL+AE.</p> <p>Case presentation: A 4-year-old male child was admitted to our hospital after presenting with a neck mass persisting for over 2 months and a fever lasting 5 days. The initial symptom was fever accompanied by lymph node enlargement. The patient was diagnosed with HNL, however, the condition did not respond significantly to treatment, and he continued to have lymph node enlargement and intermittent fever. Six months later, the patient developed neurological symptoms, including decreased voluntary activity, impaired speech, and reduced appetite. Subsequent serum testing yielded positive results for CASPR2, leading to a diagnosis of CASPR2 antibody-associated encephalitis. The final diagnosis was HNL+AE, which improved after finding the corresponding treatment. Subsequent follow-ups indicated no recurrence.</p> <p>Conclusions: This represents the first documented case of HNL+AE in pediatric patients exhibiting typical symptoms of fever, lymph node swelling and pain accompanied by acute neurologic symptoms, and an extended disease course. This report contributes to the theoretical understanding of the disease.</p> 2024-02-03T00:00:00+00:00 Copyright (c) 2024 A Study To Analyse The Integrity Of Amniotic And Amnio-Chorionic Membrane With Or Without Antibiotic Treatment By Universal Testing Machine 2024-02-07T10:25:48+00:00 Hemavathy S, Mary Antony Praba*, Venkataramaniah C s@s.b <p>This is a study that compares the tensile strength of the amniotic and amnio-chorionic membrane obtained from ‘C’ section deliveries. Amniotic membrane in recent days are very much used for complex wound healing in all types of wounds, because of the collagen bundles present in them. We formulated this study to analyse the quality and integrity of collagen bundle with or without antibiotics during collection and transportation of placenta form ‘C’ section deliveries that is widely preferred.</p> <p>We designed this study with 4 groups of samples, A-WA, A-WOA, C-WA and C-WOA with 6 samples in each group (Table-1). All the samples were processed, dehydrated, dried, cut into dumbbell shaped pieces and tested for their tensile strength. In this study the amniotic and amnio-chorionic membranes processed without antibiotics have shown high tensile strength or high membrane integrity and so can be concluded as effective in wound healing, than the counterpart.</p> <p>&nbsp;</p> 2024-02-07T00:00:00+00:00 Copyright (c) 2024 Congenital Anomalies Of Female Genital Tract And Its Effect On Reproduction 2024-02-19T12:05:34+00:00 Dr. Radhika Parmar, Dr. Aditi Atodaria, Dr. Shruti Naria, Dr. Kishor Chauhan, s@s.b <p>INTRODUCTION</p> <p>Congenital malformations of the female genital tract are defined as deviations from normal anatomy resulting from embryonic maldevelopment of the Müllerian or paramesonephric ducts. It includes malformations that affect the development and morphology of the Fallopian tubes, uterus, vagina and vulva, with or without associated ovarian, urinary, skeletal or other organ malformations</p> <p>&nbsp;</p> <p>AIMS AND OBJECTIVES</p> <p>To study the congenital malformations of the female genital tract and its effect on reproduction.</p> <p>&nbsp;</p> <p>METHODOLOGY</p> <p>This study was conducted in the department of obstetrics &amp; gynaecology at Dhiraj Hospital, Waghodia, Piparia over a period of 18 months and loo patients were included in the study,</p> <p>&nbsp;</p> <p>STATISTICAL METHODS</p> <p>Data was analysed and appropriate statistical methods like Mean, Median, Mode and chi-square test was employed to analyse data throughout study.</p> <p>&nbsp;</p> <p>RESULTS AND CONCLUSION</p> <p>After the work up of the patient and detecting the anomaly, it has been classified and can further guide the patient for the intervention required. From this study we find out the types and incidence of the congenital anomalies and also see its effect on reproduction, evaluate the factors leading to infertility and have explained about the preventive measures for that or treat the cause behind these anomalies as early as possible..</p> 2024-02-19T00:00:00+00:00 Copyright (c) 2024 Assess The Knowledge Regarding Infection Prevention And Control Measures Among Nurses Working In Maternity Units 2024-02-21T09:27:24+00:00 Ms. Salikaben Vadiya* Dr. Ningthoujam Sujita Devi s@s.b <p>Introduction: Many People are getting hospital acquired infection. Infection Prevention control is approach which help to prevent health care workers and patients from being affected by the infections which are avoidable. Aim of the study: To assess the knowledge and factors impacting adherence towards infection prevention control measures among nurses working in maternity units from selected hospitals of Pune city. Objectives of the study are to assess the level of knowledge related to infection prevention and control measures among nurses and to associate the level of knowledge score with selected demographic variables. Material and method: Quantitative research approach and Non experimental research group design was used. 220 staff nurses were selected by Non probability purposive sampling technique. Data collected through self made tool. Reliability was done by using Test-Retest method. r value for knowledge Questionnaires tool is 0.96, tools are found reliable for the study as&nbsp; r value&nbsp; was more than 0.7. Result: Majority (26.8%) were from 25-30 years of age group. Maximum nurses were from GNM(51.8%) professional qualification .Most of the sample’s designation was staff nurse(86.4%).Maximum nurses(41.8%) had 1-5 years of total years of experience. Majority of the nurses (45.5%) had total 1-5 years of experience in maternity units. Among all the staff nurses majority had hospital training(64.5%) as any exposure of training related to infection prevention and control measure. 63.6% of them had average knowledge .The demographic variables age, professional qualification, designation, total year of experience and total years of experience in maternity units were found to have a significant association with the knowledge among nurses working in maternity units regarding infection prevention and control measures as p value is less than 0.05.Conclusion: The study concluded that staff nurses had average knowledge of infection prevention and control measures.</p> 2024-02-21T00:00:00+00:00 Copyright (c) 2024