Effects of Mito-Q on cognitive and motor function in a rat model of Huntington's disease after 3-NPA-induced mitochondrial stress
Keywords:
Mito Q, Huntington's Disease, Antioxidant, 3-NPA, Oxidative stress.Abstract
Purpose: Huntington disease (HD) is caused by development of mutant huntingtin protein which primarily affects the CNS and peripheral organs. In addition to the loss of motor coordination it also causes mental and behavioral changes, weight loss and bioenergetics deficiency.
Methods: The study investigated the neuroprotective effect of mito Q against 3-Nitropropionic acid (3-NPA) induced HD in rat. Motor coordination, Locomotor activity and alterations in learning-memory were assessed. Brain striatum oxidative stress, nitrosative stress, acetyl cholinesterase level, inflammatory markers- IL-6 & TNF-α and BDNF level were assessed. The mitochondrial enzyme complex-I, II and IV were also assessed. Co enzyme Q was used as positive control.
Results: Treatment with mito Q significantly attenuated 3-NPA induced weight loss, improved locomotion, motor coordination and memory as well as improvement in biochemical parameters.
Conclusion: It can be concluded that mito Q showed a neuroprotective effect in 3-NPA induced HD animal model. It can be a promising drug for various neurodegenerative disorders
