Ultra Deformable Vesicular System Loaded Bioactive/Phytoconstituents for Targeted Drug Delivery for the Treatment of Rheumatoid Arthritis– An Overview

Abstract

In the past few years, transdermal medication delivery has emerged as the most advantageous method. It overcame many drawbacks associated with the oral route of drug administration, the most advantageous route limitation being first-pass metabolism. Although a transdermic delivery system has been created, some drugs' particles are unable to effectively penetrate the stratum corneum, which presents challenges for drugs that can be administered via this route. Our scientists and researchers have created a novel system known as the ultra-deformable vesicle system to meet this challenge (UDV). Scientists can readily penetrate deeply into the skin with this system's drug-delivery vesicles, which can contain either synthetic or natural drug molecules. Among Transferosomes and Ethosomes Transethosomes is a novel prospect for enhanced transdermal drug delivery through the skin. Rheumatoid Arthritis is a common autoimmune disorder that can cause painful joints with swelling along with bone and cartilage damage. RA is the most common type of Arthritis nowadays. There are various factors are there which are responsible such as age, body mass index, and other disease activities. 0.75% of the Indian population is suffering from arthritis among these the most common is Rheumatoid Arthritis and Osteoarthritis. Nowadays scientists and researchers are more focused on nanomedicine for the treatment of arthritis. They are aiming for synthetic drugs loaded in nanoparticles to easily target the arthritic site in the patient suffering from Arthritis. But the nanoparticles loaded with synthetic drugs have some drawbacks such as drug adverse effects. To overcome these limitations plant-based medicines have received a lot of attention in recent years. The current review work on herbal drugs has mostly focused on different phytoconstituents which can be used for the targeted drug delivery for the treatment of Rheumatoid Arthritis.