A New Binuclear La Schiff Base Complex: Therapeutic Activity on Breast Cancer Combined with Focused Ultrasound

Abstract

In this present study, a new dinuclear La(III) coordination complex, namely [La(dbm)2
HL(CH3
OH)]2
·2CH3
OH (dbm = 1,3-diphenylpropane-1,3-dione, HL = N’-[(1E)-[5-(hydroxymethyl)furan-2-yl]methylidene]pyrazine-2-carbohydrazide) has been successfully prepared via a solvothermal method which was further characterized by elemental analysis, IR and single crystal X-ray diffraction. Its clinical
treatment value against breast cancer was evaluated and the related mechanism was explored at the same
time. Firstly, the inhibitory activity of the new compound on the viability of the breast cancer was measured
with CCK-8 assay. Besides, the migration and invasion of the cancer cells was also assessed by the trans-well
assay after the compound treatment.