Analgesic and Sedative Effect of Oxycodone in Postoperative Patient-Controlled Intravenous Analgesia for Patients Undergoing Transurethral Resection of Prostate

Abstract

This study investigated the analgesic and sedative effect of oxycodone in patient-controlled
intravenous analgesia (PCIA) for patients undergoing transurethral resection of prostate (TURP). Sixty patients undergoing TURP were divided into oxycodone and sufentanil groups. In PCIA, the oxycodone group
used oxycodone hydrochloride and the sufentanil group used sufentanil citrate. At postoperative 6 h and 12
h, the Visual Analogue Scale score in oxycodone group was significantly lower than sufentanil group (p <
0.05). Within postoperative 48 h, the frequency of PCIA pump presses and number of bladder spasm cases
in oxycodone group were significantly less than sufentanil group (p < 0.05). At postoperative 12 h, the serum
5-hydroxytryptamine and substance P levels in oxycodone group were significantly lower than sufentanil
group (p < 0.05). Within postoperative 48 h, the incidence of drowsiness, dizziness, nausea and vomiting in
oxycodone group was significantly lower than sufentanil group (p < 0.05). In conclusion, oxycodone has good
analgesic effect in PCIA for TURP, with few adverse reactions.