Adverse Drug Reactions Of Gliptin In Type Ii Diabetic Management

Abstract

Diabetes mellitus is a heterogenous disorder of inadequate control of blood levels of glucose. The current study is to analyze adverse drug reactions of gliptin derivative in type II diabetic management.In the study, the patients were monitored for adverse drug reaction (ADR) associated with the gliptins, other oral antidiabetic drugs (OADs), and insulin. Data collected include demographic information, comorbid conditions, diabetic duration, ADR observed, current and past medication. Causality and severity were assessed by using Naranjo’s, WHO UMC scale and modified Hartwig and Siegel scale, respectively. In the Present study, out of 146 ADRs (81 in females and 75 in males) observed from 1000 patients, were using gliptin along with other OADs. Most commonly observed ADR were related to gastrointestinal and respiratory system. Causality assessment of ADRs showed 103 ADRs as probable, 40 ADRs as possible and 03 ADRs as doubtful. Severity assessment of ADRs observed shows 106 ADRs as mild and 30 as moderate. The study was statistically significant with first, second and third review HbA1c value (< 0.031, 0.014, and 0.011) but was not statistically significant with age, diabetic history and BMI. The study concluded that ADRs associated with the use of gliptin were mostly related to gastrointestinal and respiratory system. More information about prescribed medications and their adverse effects is done to ensure patient safety.