Design And Formulation Optimization By Using Design Of Experiment Of Trilayered Sustained Release Tablets Containing An Anti-Anginal Drug

Abstract

Trilayered sustained release tablets are gaining attention as a drug delivery strategy. Such tablets can increase patient compliance and prolong therapeutic advantages. This study develops trilayered anti-anginal pills using Design of Experimentation (DoE) principles. This formulation is designed to deliver drugs slowly, maintaining bloodstream drug levels. Anti-anginal therapy requires bloodstream drug stability. Angina pectoris, a sign of coronary artery disease, still plagues people worldwide. Nitrates and beta-blockers reduce angina symptoms and improve patient quality of life. To achieve the intended prolonged release profile, suitable excipients were needed during formulation development. Hydrophilic polymers and matrix-forming agents may control medication release better than other choices. To refine the formulation, DoE was used. A Central Composite Design (CCD) examined how independent elements like polymer composition, tablet hardness, and drug loading affected dependent responses like drug release patterns and tablet characteristics. The trilayered pills have two drug release profiles: burst and sustained.