Enhancing The Solubility Of Prasugrel Hydrochloride By Liquidolid Compacts Based On A Factorial Design Approach

Abstract

Prasugrel is a medication used to prevent formation of blood clots. It is a platelet inhibitor and an irreversible antagonist of P2Y12 ADP receptors and is of the thienopyridine drug class. Prasugrel hydrochloride is a class-II drug classified under BCS classification with low solubility and high permeability. Liquidsolid formulations were prepared using Labrafac, Avicel PH 112, and Aerosil, in different ratios, as a non-volatile solvent, carrier material and coating material respectively. Excipients and drug interactions were characterized through FT-IR. These studies showed no interaction between excipients and drug. 32 factorial design approach was implemented. The formulations were optimized using Design Expert version 13.00 (StatEase Inc., Minneapolis, MN, USA).  An optimal formulation exhibited an angle of repose of 25.5°, a hardness of 3.5 kg/cm2 and a percentage cumulative drug release of 92.54 % after 10 minutes. The observed values were found to be similar to the predicted values. Based on these observations, PSG-O can be considered to be the optimum formulation.