Development and Characterization of Gastroretentive Drug Delivery System of Nifedipine

Abstract

The study's goal was to create a Nifedipine medication delivery method with improved gastro retention. The tablets were created using Carbopol 934P, HPMC K4M, and HPMC K15M in a direct compression process. To shorten the floating lag time, sodium bicarbonate was employed as the gas-generating agent. The tablets' hardness, weight fluctuation, thickness, floating capacity, swelling index, medication content, and in vitro dissolution study all underwent evaluation. The formulations used nonfickian (anamalous) diffusion as the mechanism for releasing all of the floating tablets made with different types of polymers