Investigation of Possible Hypoglycemic and Hypolipidemic Effect of Ethanolic Extracts of Phyllanthus niruri and Phyllanthus acidus

Abstract

The objectives of the present study were to assess the preliminary antihyperglycemic and anti-hyperlipidemic effects of Phyllanthus niruri and Phyllanthus acidus ethanolic extract in several animal models. The antihyperglycemic and hypoglycemic effects of Phyllanthus niruri and Phyllanthus acidus ethanolic extracts were examined in glucose-overloaded hyperglycemic rats and overnight starved normal rats. Rats with hyperlipidemia brought on by Triton were also used to test the extract's antihyperlipidemic potential. The two dose levels used for each approach were 200 and 400 mg/kg, respectively. The study's findings were presented as mean SEM, n=6, and the data was analysed using one-way analysis of variance (ANOVA) and the Bonferroni Multiple Comparison Test with a 5% level of significance (P≤0.05).At 400 mg/kg, the ethanol extract of Phyllanthus niruri and Phyllanthus acidus significantly reduced blood sugar levels in normal fasting rats (P0.05). Additionally, hyperlipidemic rats showed a statistically significant dose dependant decrease (P≤0.05) in the serum lipid profile, including total cholesterol, triglycerides, low density lipoprotein (LDL), and very low density lipoprotein (VLDL), and an increase in high density lipoprotein (HDL). This study backs up the conventional wisdom that these plant's ethanolic extract has significant hypoglycemic and hypolipidemic effects. It can be added to traditional preparations to treat complications brought on by hyperglycemic and hyperlipidemic conditions, or it can be used as an adjuvant to already prescribed treatments.