Formulation Development And Characterization Of Docetaxel Loaded Microsponge Based Hydrogel For The Treatment Of Basal Cell Carcinoma

Abstract

Researchers wanted to develop skin liposomal formulations that would transport 5-fluorouracil to the cancer site in an adjuvant manner in addition to enhancing the health of basal cell carcinoma patients who were experiencing adverse effects. The Korsmeyer-Pepas condition was deemed to be the best condition to manage drug administration after the 5-fluorouracil sensitivity via Strat-M films and the detailed skin damaging potential of the created skin liposomes were evaluated in vitro. Its potential to irritate the skin is also unknown. The viability and hemolytic potential of the cytostatic effect on the suggested anti-tumor therapy were also investigated in in vitro investigations. According to our research, a sodium alginate and hyaluronic acid crosslinked gel containing AS1411 aptamer liposomes coated with 5-fluorouracil is the optimum liposome solution. This liposome characterization seems to have positive implications for biological safety and may be employed as an alternative therapeutic approach for basal cell carcinoma skin therapy.