Formulation And Evaluation Of Fast Disintegrating Tablet Of Anti Inflammatory Drug Using Natural Superdisintegrant

Abstract

In the development of fast disintegrating tablets, seed gum and its carboxymethyl derivatives extracted from Tamarindus indica seeds were used as pharmaceutical disintegrants. The chemical structure of the seed gum was modified through carboxymethylation.The process involved the chemical modification of the extracted gum from tamarind seeds through carboxymethylation. This modification aimed to enhance the hydrophilic nature of the gum. Additionally, calcium complexation of the carboxymethylated tamarind seed gum was carried out. Fast disintegrating tablets were then prepared using the direct compression method. The disintegration time of these tablets, containing the calcium-complexed tamarind seed gum, was compared to tablets formulated with a commercially available superdisintegrant, crospovidone. The disintegration time of the tablets with the calcium-complexed tamarind seed gum was reported to be 1 minute, approximately 32.5 seconds, and 35.2 seconds, respectively, indicating good disintegrating properties.In conclusion, the use of modified tamarind seed gum as a natural superdisintegrant in fast-dissolving tablets was found to accelerate tablet dissolution, providing a promising alternative for formulating tablets with improved disintegration properties.