Role of Adaptive Immunity and Oxidative Stress in Neurodegenerative Disorders A review
Keywords:
Adaptive immunity, ROS, Neurodegenerative disorders, Alzheimer's disease, neuroinflammationAbstract
Background: Millions of people are impacted by neurodegenerative disorders like Alzheimer's, which place a heavy personal and societal burden. Most of the time, the reasons for neurodegeneration are unknown, but recent research has identified an autoimmune component to these illnesses. Several neurologic disorders, including Alzheimer's disease, Parkinson's disease, Huntington's illness, and amyotrophic lateral sclerosis, are thought to be brought on by a genetic flaw connected to a particular molecule and the age-related aberrant production of free radicals.
Aim: Role of adaptive immunity and oxidative stress in neurodegenerative disorders.
Methods: A thorough search was conducted in several databases, including Scopus, Embase, Cochrane, and PubMed. Alzheimer's disease, mechanism of action, neuroinflammation, Mast cells react to stress and neuroinflammation. The study included all publications published in English.
Results: The primary elements in the pathophysiology of Alzheimer's disease are free radicals. Potential therapeutic targets include free radicals. Numerous studies have linked chronic stress to several neuroinflammatory processes, and there is strong evidence for this association. Mast cells react to stress and neuroinflammation. In the pathophysiology of stress-related neuroinflammation and neurodegeneration, mast cells have an important function. Alzheimer's disease, characterised by increasing dementia and cognitive impairment, affects over 24 million people worldwide today because mast cells and free radicals play the main role in the causes of neurodegenerative illnesses.
Conclusion: Various neuroinflammatory processes, including long-term stress, increase the risk of neurodegeneration. Understanding how mast cells contribute to the aetiology of stress-related neuroinflammation and neurodegeneration is critical. These pathways provide a foundation for developing medications to treat neurodegenerative diseases.
