Preparation and In-Vitro characterization of solid dispersion tablets using effervescent, sublimation, and Effervescent with swelling system control release approaches to improve floating capabilities of Cilostazol

Abstract

The research focused on improving the floating capabilities of Cilostazol, a drug used for its antiplatelet and vasodilatory effects, through the preparation of solid dispersion (SD) tablets using three different approaches: effervescent, sublimation, and effervescent with swelling system control release. First prepared SDs of Cilostazol using hydroxypropyl methylcellulose (HPMC) as a carrier in various ratios. These SDs were then characterized in vitro to assess their solubility, drug content percentage, and dissolution studies. It was observed that the dissolution rate significantly increased with the use of entirely SDs, indicating the effectiveness of this approach. Tablets were formulated using the optimized SD products, and various parameters were evaluated to determine the quality of the formulations. Among all the tablet formulations, the F4 formulation exhibited the best results in terms of pre-compression and post-compression parameters. It possessed the desired qualities of a good swellable and floating gastroretentive tablet, which led to its selection as the best formulation. The release data obtained from the in-vitro studies were fitted into several kinetics models to elucidate the release mechanism. The F4 formulation demonstrated zero-order release, indicating a consistent and controlled drug release profile. From the findings, it can be concluded that the use of swellable and floating gastroretentive tablets containing SDs of Cilostazol can effectively achieve the desired therapeutic objective. By improving the drug's dissolution rate and controlling its release, these formulations offer potential benefits for enhancing the drug's efficacy and therapeutic outcomes.