A Comparative Study Of Polyherbal Plants For The Management Of Streptozotocin-Induced Diabetes In Rats

Abstract

Background: In Type I DM, beta cell death is prevalent, which results in insulin insufficiency and causes a number of problems. Through this study, we hope to learn more about the potential anti-diabetic properties of Aegle marmelos, Moringa oleifera, and Syzygium cumini. Objective: The objective is to explore the methanolic extraction of plants for the toxicity study, proliferation and protection of pancreatic beta cells in-vivo model, and Influence the GLUT2 and GLUT4 expression. Materials and Methods: Diabetes was induced by a single injection of STZ 65 mg/kg, b.w. i.p., at the end of the study, blood was drawn from the rats to conduct the following tests: blood glucose level, Serum & Pancreatic Insulin, C-Peptide, HbA1c, Lipid profiles, Pro-inflammatory cytokines, antioxidant enzymes, and Expression of GLUT 2 and GLLUT 4 by use of western blot. Key Findings: All three plants were found safe, with no mortality at a dose of 5000 mg/kg. Comparatively Moringa oleifera, Aegle marmelos and Syzygium cumini produce greater serum and pancreatic insulin. Pro-inflammatory cytokines were decreased after receiving test drugs. In comparison to their control group, all other diabetic markers, including blood glucose and lipid profiles, displayed a dose-dependent pattern. C-Peptide and HbA1c, antioxidant enzymes, also showed considerable improvement. In the liver and skeletal muscle, the plants increased GLUT2 and GLUT4 gene expression. Conclusion: The plant extract had Insulino-mimetic effects and potential to protect beta cells from oxidative and cytotoxic stress.