Precipitation Inhibitors In Smedds / Sedds: A Comprehensive Review

Abstract

A self-emulsifying drug delivery system (SEDDS) is one of the most significant innovative achievements in the area of enhancing the solubility of pharmaceuticals that aren't highly water-soluble. SEDDS are employed to increase the bioavailability of medications with poor solubility. These are stable O/W emulsions. SEDDS are subject to a number of limitations in terms of likely in-vivo precipitation due to the presence of a highly saturable solution. Due to this, the in-vitro-in vivo correlation is poor, and the medication's stability when it enters the GI fluid is low. One straightforward way to get around this problem is to include precipitation inhibitors (PIs) in the SEDDS system, which makes the system stable without running the risk of potential precipitation in the gastrointestinal tract. These PIs are used to balance the formulation under the super saturable situation. Several PIs are listed in this article along with their potential applications. Both the film technique and the solvent shift methods can be used to evaluate PI scans.