Thiazole Derivatives As Potential Therapeutic Agents For Cancer Treatment: A Review Of Structure-Activity Relationships

Abstract

One of the leading causes of mortality worldwide is cancer. Despite the significance of fighting cancer in healthcare systems and research facilities, chemotherapy has significant concerns due to the toxicity of normal tissues and the ineffectiveness of anticancer medications. Discovering novel, safer, and more potent anticancer medicines is the focus of many current medical research efforts. Due to their extensive spectrum of biological actions, which include anticancer properties, thiazide compounds are significant components in medicinal chemistry. The objectives of this review are to provide an overview of the structure-activity relationships, and pharmacological outcomes of thiazole derivatives. There are several classes of thiazide derivatives with anticancer action, with examples including Schiff bases, mono-, di-, tri-, and heterocyclic substituents. The paper also goes into detail on the molecular modelling of substances that forecast increased anticancer activity of the changed structures. Overall, this review provides valuable insights into the potential of thiazole derivatives as therapeutic agents for cancer treatment and highlights the importance of understanding their structure-activity relationships.