Evaluation of Antiulcer Activity of Ethanolic Extract of Ipomoea carnea Jacq. in Rats

Abstract

Background: The current study has been investigated to determine the anti-ulcer potential of ethanolic extract of aerial part of Ipomoea carnea Jacq. (convolvulaceae) in rats.

Methods: Using a pylorus ligation-induced ulcer model in Wistar Albino rats, the antiulcer activity was assessed. The study consisted of six groups containing six animals each. Group I served as Normal control; Group II served as Ulcer control; Group III served as Reference group and received Omeprazole (30 mg/kg b.w.; orally); and Group IV-VI served as test groups and received ethanolic extract of Ipomoea carnea (100, 200, and 400 mg/kg b.w.; orally). All the groups received the dose 1 h prior to pyloric ligation. Four hours following pyloric ligation, the gastric juice was taken for the assessment of numerous parameters. Gastric volume, ulcer index, pH, free acidity and total acidity in the gastric juice of pyloric-ligated rats were used to measure the antiulcer activity. Moreover, the parameters of oxidative stress like lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were also assessed.

Results: A significant (p<0.05) decrease in gastric volume, ulcer index, free acidity and total acidity in the gastric juice of pyloric-ligated rats served as evidence that the ethanolic extract (EE) of aerial part of Ipomoea carnea Jacq. (AIC) had antiulcer activity on pyloric ligation-induced ulcer in rats in a dose-dependent manner. Also, the pre-treatment with EE of AIC significantly lowered the increased LPO and SOD levels. In addition, the decreased GSH and CAT levels were increased in pyloric-ligated rats in a dose dependent manner.

Conclusion: The current study demonstrated that the EE of AIC possessed significant dose-dependent antiulcer activity in pylorus ligated rats.