Antiulcer Activity of Hydromethanolic Extract of Ipomoea carnea Jacq. in Rats

Abstract

Ipomoea carnea Jacq., regarded for its untapped biological potential, is a momentous folkloric medicinal plant. The aim of the current study was to investigate the antiulcer activity of hydro-methanolic extract of aerial part of Ipomoea carnea Jacq. (convolvulaceae) in rats. The antiulcer activity was tested using a rat model of pylorus ligation-induced ulceration. Six groups with six animals each comprised the study. Groups I and II served as the normal and ulcer control respectively, Group III as the reference group and got omeprazole (30 mg/kg b.w.; orally), while Groups IV-VI served as the test groups and received hydromethanolic extract (HME) of Ipomoea carnea (IC) (100, 200, and 400 mg/kg b.w.; orally) as the intervention. One hour before pyloric ligation, the dose was administered to all groups. The gastric juice was collected for the evaluation of many parameters four hours after the pyloric ligation procedure. Measurements of the antiulcer activity included gastric volume, ulcer index, pH, free acidity, and total acidity in the gastric juice of pyloric-ligated rats. Additionally, the markers of oxidative stress were evaluated, including lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT). Evidence that the hydromethanolic extract (HME) of the aerial part of Ipomoea carnea Jacq. (AIC) had antiulcer activity on pyloric ligation-induced ulcer in rats was provided by a significant (p<0.05) decrease in gastric volume, ulcer index, free acidity, and total acidity in the gastric juice of pyloric-ligated rats. Additionally, the elevated LPO and SOD levels were dramatically reduced by the pre-treatment of AIC with HME. Additionally, in pyloric-ligated rats, the reduced GSH and CAT levels increased in a dose-dependent manner. In conclusion, the current work showed that in rats with pylorus ligation, the HME of AIC had strong dose-dependent antiulcer action.