Preparation and Evaluation of Polyherbal Powder for Treatment of Diabetes Mellitus through Their Preformulation Parameters

Abstract

Diabetes is a silent killer that causes significant economic damage in various developing and developed nations. To reduce the strain on a person's health and economy as well as the burden on society as a whole, better therapies must be developed with fewer side effects. Polyherbal preparation is also a better option in the modern medical age for the treatment of diabetes compared to the other allopathic medicine. Polyherbal powder has been prepared with Azadirachta indica leaves, Cinnamomum zeylanicum barks, Terminalia bellirica fruits, and Withania somnifera roots for diabetes mellitus in the present work and evaluated the powder based organoleptic, rheological, physico and phytochemical properties. On the basis of the earlier scientific research work mentioned in the scientific fields, Azadirachta indica leaves, Cinnamomum zeylanicum barks, Terminalia bellirica fruits, and Withania somnifera roots have been utilised in the present work to make the polyherbal powder. Standard practises were used to evaluate all the parameters. The polyherbal powder's organoleptic characteristics were determined and found to be a dull brown colour, distinctive odor, astringent taste, and a reasonably fine texture. The presence of flavonoids, alkaloids, terpenoids, tannins, steroids, carbohydrates, and glycosides was detected in the phytochemical qualitative test. The polyherbal powder shows impurities in the form of ash values basically silica and calcium oxalate that was found to be 5.66±0.93, acid insoluble ash value obtained 1.66±0.19, water soluble ash value obtained 3.02±0.29. According to physicochemical examination, the polyherbal powder had prolonged stability and good flow characteristics. The values obtained for flow properties i.e. bulk density was 0.79±0.065, tapped density 0.85±0.061, Hausner’s ratio 1.08±0.02, Carr’s index 4.53±0.79 and angle of repose for polyherbal powder was 29.9±1.27. Polyherbal powder's organoleptic characteristics were determined in the present work which could be used for the development of better and effective polyherbal formulation to treat diabetes mellitus in the future.