Evaluation of Antiulcer Activity of the Hydromethanolic Extract of Aerial Parts of Ipomoea carnea Jacq. in Rats

Abstract

Ipomoea carnea Jacq., which is prized for its unrealized biological potential, is a significant folklore medicinal plant. The current study's objective was to examine the hydro-methanolic extract of the aerial part of the convolvulaceae plant Ipomoea carnea Jacq.'s antiulcer activity in rats. Thirty-six animals, divided into six groups of six rats each, were used in the study to evaluate the antiulcer activity. All the rats were starved for 24 h. After the fasting period, Indomethacin (40 mg/kg, p.o.) was given. All samples of the plant extract were given 60 min prior to Indomethacin as follows: Group I animals received distilled water (0.5 mL/kg b.w.; orally) and served as control. Group II animals received distilled water (0.5 mL/kg b.w.; orally) and served as ulcer control. Group III rats received Omeprazole (30 mg/kg b.w.; orally), and served as the reference drug group for comparison. Groups IV, V and VI received EIC orally at 100, 200, and 400 mg/kg b.w., respectively. The gastric juice was taken for the assessment of numerous parameters. Measurements of the antiulcer activity included gastric volume, ulcer index, pH, free acidity, and total acidity in the gastric juice of pyloric-ligated rats. The indicators of oxidative stress, such as lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT), were also assessed.

The hydromethanolic extract (HME) of the aerial part of Ipomoea carnea Jacq. (AIC) had a significant (p0.05) decrease in gastric volume, ulcer index, free acidity, and total acidity in the gastric juice of Indomethacin-induced (InI) rats, which was proof that it had antiulcer activity on InI ulcer in rats. Additionally, pre-treating AIC with HME significantly decreased the increased LPO and SOD levels. A dose-dependent increase in the lowered GSH and CAT levels was also seen in InI animals. In coclusion, in the current study, AIC's HME displayed potent dose-dependent antiulcer effect in rats.