Development and Optimization of Sustained Release Tablets for Alfuzosin Hydrochloride using Different Polymer Matrices
Keywords:
Alfuzosin HCl, HPMC K 100M, Ethyl Cellulose, release kinetics, Sustained release tablets, polymer matrices drug efficacy, BPHAbstract
Background
The aim of this study was to determine the formulation of sustained release tablets using different classes of polymers to enhance drug efficacy and provide prolonged relief for benign prostatic hyperplasia (BPH) and hypertension. The two different polymers i.e.; hydrophilic polymer HPMC K 100M and Hydrophobic polymer EC was considered as an independent variable in a factorial design, and drug release at 1, 6, 12, and 20 hours was selected as the response variable. The primary objective of this study was to develop a medication that eliminates the need for multiple daily dosages for BPH and hypertension. Therefore, the focus was on creating a sustained release tablet that could offer a synergistic effect and provide prolonged relief. By optimizing the formulation, we aimed to enhance drug efficacy and minimize the frequency of drug intake.
Results
Dissolution studies revealed that the optimized formulation achieved sustained drug release over a 20-hour period, with a release profile fitting Higuchi kinetics. The release rate was dependent on the polymer concentration, with optimized ratio of HPMC and Ethyl-cellulose based tablets exhibiting the best drug release pattern. Physicochemical characterization, including tablet hardness, weight uniformity, and content uniformity, met the specified requirements.
Conclusion
This study successfully developed and optimized sustained-release tablets for AFH using different polymer matrices. The findings suggest that these formulations have the potential to offer an effective treatment option for BPH, with improved patient compliance and reduced side effects. The use of HPMC and EC as release-controlling agents provides flexibility in tailoring the drug release rate to meet specific therapeutic needs. Overall, this research contributes to the field of pharmaceutical formulation development and the optimization of sustained-release drug delivery systems.
