Phytochemical And Pharmacological Investigation On The Aerial Parts Of Allium Cepa For Anti- Inflammatory And Analgesic Activity

Abstract

The Objective of this study was to evaluate the anti-inflammatory and analgesic activities of the ethanolic and petroleum extract of the aerial parts of Allium cepa in animal models. The anti-inflammatory effect was evaluated by carrageenan- induced paw edema method. Also, the analgesic effect was examined by hot plate test. The ethanolic and petroleum ether extract of Allium cepa could reduce the edema in a dose-dependent manner (P<0.05). The ethanol and petroleum ether (but not the other fractions) showed significant analgesic activity in hot plate test, when compared to pentazocine. The results of this study demonstrated the anti-inflammatory and analgesic effects of ethanolic and petroleum ether extract in animal models and justify traditional use of this plant in the treatment of pain and inflammatory conditions. More studies to clarify the active components are necessary