Formulation And Evaluation Of Sustained Release Matrix Tablet Of Nitrofurantoin

Abstract

The main objective of the present work was to develop sustained release matrix tablets of Nitrofurantoin. To reduce the frequency of administration and to improve the patient compliance, a twice daily sustained release formulation of Nitrofurantoin is desirable. So sustained release Matrix tablet of Nitrofurantoin was designed by using different polymers viz. Hydroxyl Propyl Methyl Cellulose (HPMC K4M, K100M), and natural polymer like xanthan gum at varying ratios of drug and polymer were selected for the study. The IR study revealed that there was no chemical interaction between drug and excipients. The tablets were prepared by direct compression method. Pre-compressional parameters i.e. angle of repose, percent compressibility, and Hauser’s ratios were studied. These results indicate that powder blend had good flow characteristics. After evaluation of physical properties like Weight variation, Hardness, Thickness, Friability of tablet, the different formulations were checked for the percentage Drug content, which showed good uniformity. The in vitro release study was performed in 0.1NHCl for first 2 hrs and in phosphate buffer pH 6.8 up to 12 h. The effects of polymer concentration were studied. Dissolution data was analyzed by Percentage cumulative drug release. Matrix tablets studied for the different polymer ratios and performance checked for different concentration ratios. The results of drug dissolution studies showed improved drug release, retardation effects of the polymers and could achieve better performance. It was observed that matrix tablets contained mixture of natural and synthetic polymer successfully sustained the release of drug up to 12 hrs.