Nano-enabled delivery of anesthetics- Evaluated in preclinical studies

Abstract

Background: Hydrogels are being studied increasingly as local drug delivery methods because of their malleable features, adaptable degradation, and capacity to preserve labile pharmaceuticals. However, the shortage of standardized methodologies needed to characterize and calculate drug exposure, it is difficult to compare the results which hinders an accurate assessment of systems. When dealing with soft-tissue lacerations in an emergency, topical anesthesia rather than injecting local anesthetics (LAs) may be more comfortable for the patient and the surgeon. Aim and objectives: As a topical anesthetic on the skin and, in certain cases, of short surgical therapy, cream-based eutectic mixes of Local Anesthetics (Las) (EMLA®), Lidocaine gel, Lidocaine Snedds, Bupivacaine gel, and Bupivacaine Snedds are effective alternatives to inject able anesthesia before venipuncture. The objective of this research is to compare the pharmacokinetics of EMLA, Lidocaine gel, Lidocaine Snedds, and Bupivacaine gel if applied topically on mouse skin and to a laceration. Methodology: Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used to analyze the plasma samples, and conventional non-compartmental approaches were applied to estimate the pharmacokinetic analyses. Conclusion: Additional pharmacokinetic studies of lidocaine and Bupivacaine with different carriers are required prior to the preclinical being able to establish conclusive findings.