Ameliorative Effect Of Glycyrrhiza Glabra Against Copper Sulphate Induced Neurotoxicity In Drosophila Melanogaster

Abstract

The harmfulness of metals can vary based on concentration, length of exposure, sensitivity, and chemical makeup. Although trace elements such as copper are necessary for our bodies to function properly, excessive exposure can have negative consequences. This particular study delves into copper sulphate, a trace element that can be harmful due to its ability to attach to proteins in organisms. Too much copper can damage cells and negatively impact health, which is why research is crucial to address its toxicity. Medicinal plants like Glycyrrhiza glabra (licorice) are renowned for their potential health benefits. It has been found that Glycyrrhiza glabra possesses compounds with metal chelating abilities that could potentially help mitigate copper toxicity. In order to explore this further, an experiment was conducted using the Drosophila melanogaster model. This model is ideal for toxicological studies due to its physiological and biochemical resemblance to mammals. The experiment involved administering copper sulphate and licorice extract to fruit flies through their diet. We observed and analysed the interaction between different substances. In order to evaluate the effect of licorice on copper toxicity, we conducted enzymatic tests (Superoxide dismutase, catalase) and quantitative tests (Lowry, Lipid peroxidation). The results of the tests showed that licorice has the ability to counteract the harmful effects of copper sulphate. Through the enzymatic and quantitative assays, we gained insight on the defence mechanisms of licorice against copper toxicity. This study provides valuable information on natural remedies for metal toxicity and highlights the potential of medicinal herbs, such as Glycyrrhiza glabra, in reducing the adverse effects of metal exposure.