Formulation And Evaluation Of Ibuprofen Mouth Dissolving Tablet By Using Crospovidone Croscarmellose Sodium

Abstract

Objective: The aim of the present investigation was to design and evaluate mouth dissolving tablet (MDT)of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop MDT of Ibuprofen using superdisintegrants forease of administration and its physicochemical characterization.

Methods: Tablets were made from blends by direct and wet compression method. All the ingredients were passed through mesh no. 80. All the ingredientswere co-ground in a pestle motor. The resulting blend was lubricated with magnesium stearate and compressed into tablets.

Results: Physicals parameters of the prepared tablet slike Hardness,Weight variation, Friability, thickness, drug content, wet ability etc. found within the limits. The disintegration time of prepared MDTs was in the range of 20 to 51 seconds. In vitro dispersion time was found to be 42 to 66 seconds which may be attributed to faster uptake of water due to the porous structure formed by super disintegrants. Short disintegration and faster release of ibuprofen were observed with Crospovidone as compared to Croscarmellose sodium.

Conclusion: It is concluded that F2 and F5 offered the relatively rapid release of Ibuprofen when compared with other formulations. The increase in the concentrations of super disintegrants may lead to increase in the drug release. The formulation prepared with Crospovidone was

Offered the relatively rapid release of Ibuprofen when compared with other concentrations of both the super disintegrant.