In- Situ Gel: Ocular Drug Delivery System

Abstract

The protective layers that cover the eyes impede drug transport to the ocular region, and because the bulk of the ocular stay is precorneal, it has always been difficult to demonstrating good bioavailability of the active ingredient in the ocular region. Many delivery systems are unable to properly treat eye illnesses because direct delivery techniques mix oil, solution, and suspension in addition to other substances. Numerous attempts have already been made and continue to be made to overcome this issue, among them which is the application of in-situ polymers system construction. When implanted or inserted into an ocular cavity, where active medications are continually administered, and ocular in-situ gelling devices swiftly convert from a solution to a thick gel. Changes in pH, the presence of ions, and temperature are only a few of the variables that affect the conversion of the sol to gel phase. This paper briefly discusses in-situ gels, in-situ gelling systems, the various kinds of polymers utilized in them, gel-based processes, and in-situ gel polymeric testing.