Anti-Diabetic Activity Development And Evaluation In Polyherbal Tablets Of Local Herbs

Abstract

Diabetes is of the metabolic disorder that has become one of the major cause leading to morbidity and death around the globe. Anti-diabetic medications that are more effective and have adverse effects less frequently are currently being sought after. Much little study has been done on polyherbal compounds, irrespective of the fact that several individual herbs have been shown to have antidiabetic properties in studies or clinically. It is thought that herbal mixtures made of various plant products have synergistic anti-diabetic properties and may strengthen the intended results. Numerous polyherbal preparations have been investigated as potential therapeutics for the treatment of diabetes. A thorough assessment of the literature was conducted using many significant databases to characterize the present state of research on polyherbal substances for the treatment of diabetes. This research focused on the formulation and evaluation of polyherbal tablets containing extract from leaves of Phyllanthus amarus, Tinospora cordifolia, Momordica charantia, Vinca rosea available in the local areas of Sambalpur, Odisha, India. Invivo studies showed that the blood sugar lowering effect was found more pronounced in higher dose 500 mg/kg than lower dose 250 mg/kg. The efficacy of 500 mg/kg of the formulation was almost equal to that of standard therapy. Along with it oral glucose tolerance test showed increase in blood glucose level within a period of 30 mins from the starting of test as compared to the initial level of glucose concentration. This hyperglycemia was maintained until 60 min and then began to decrease. The polyherbal formulation proves to be an effective method of treatment of diabetes mellitus thus required to be explored further for better promising results.