Formulation And Evaluation For Enhancing Tolnaftate Permeation With Transferosomal Gel

Abstract

The goal of this study was to develop a Tolnaftate-loaded transferosomal gel for transdermal administration. The goal of the formulation was to improve drug penetration. Transferosomes are lipid-based vesicular carriers, were used to encapsulate the medication. It is a synthetic vesicle that resembles natural cell vesicles that can penetrate the skin intact.  Tolnaftate is a synthetic antifungal chemical that has long been used to treat a variety of fungal infections. Thin film hydration method is used to create transferosomes by changing the ratios of soya lecithin and surfactants. For the current investigation, three surfactants were chosen i.e., span 20, span 60, and span 80. The concentration of the drug was kept constant. The proportion of soya lecithin to surfactant was varied to create nine formulations. Span 60 was shown to be more effective surfactant than the other two because of its small vesicle diameter and excellent entrapment effectiveness with good stability. Among the nine formulations tested, the F6 formulation with a 2:1 ratio of soya lecithin to surfactant had the greatest entrapment effectiveness of 97.98%, drug content of 97.65%, and zeta potential of – 49mV. The drug release was extended to 12 hours, having 96.98% of the drug released from the formulation TS1. The current work investigated the impact of soya lecithin and a surfactant, on vesicle shape, entrapment efficiency and and invitro drug release.