Detail Work On Formulation Development and Evaluation of Micro sponges gel of Clotrimazole for Treatment of Vaginal fungal Infection

Abstract

The microsponge-based novel delivery system has been developed for vaginal delivery of Clotrimazole. The method adopted was quasi-emulsion solvent diffusion. Formed microsponges were a  spherical in shape Different drug–polymer ratio reflected good particle size, drug content and  entrapment efficiency. Microsponge-based gel showed in vitro drug release reflected highest  regression value for Koshmeyer-Peppas and in vitro antifungal activity of CLZ microsponges gel was higher than the market formulation. Carbopol gel could give prolong retention of the dosage form in the vagina mucosa, and increase the contact time of the drug with the vaginal mucosa. A gel containing microsponges prepared in this study was found to be promising as novel delivery system for the treatment of vaginal fungal infections. Over all f23 formulation was found to be more reliable amongst the other formulations, as production yield, entrapment efficiency,  actual drug content, %CDR and Flux was found to be (µg/cm2/h).Koshmeyer Peppas was found to be best fitted model Viscosity was measured and showed non –newtonian flow.  The ZOI was more than marketed preparation.