Comparison of analgesic effect of ropivacaine hydrochloride and bupivacaine hydrochloride in transversus abdominis plane block after hysterectomy

Abstract

Background and Aims: Total abdominal hysterectomy (TAH) is one of the commonly performed major surgical procedures resulting in substantial postoperative pain and discomfort. consequently, the study was carried out to compare the postoperative analgesic effect of Ropivacaine hydrochloride and Bupivacaine hydrochloride in transversus abdominis plane (tap) block after total abdominal hysterectomy (TAH). The primary objective became to compare the post operative analgesic duration and secondary objective become comparing the hemodynamic parameters, nausea and sedation score.

Methods: The prospective, double blind and randomized comparative trial was conducted in 60 ASA physical status I and II patients scheduled for elective total abdominal hysterectomy. Patients had been randomly divided into group A and group B and that they had been given tap block by ‘double pop off’ technique with Ropivacaine and Bupivacaine respectively. Heart rate, systolic and diastolic blood pressure, NRS nausea and sedation score had been measured.

Results: Haemodynamic variables like heart rate, systolic and diastolic blood pressure does not show large difference with p value > 0.05. Time for rescue analgesia became significantly higher in patients with group A while compared with group B with p value of < 0.001. Nausea and Sedation score also remains normal without any significant changes with p value > 0.05.

Conclusion: Bupivacaine hydrochloride gave longer duration of postoperative analgesia compared with Ropivacaine hydrochloride and there's no significant variations in hemodynamic variables, nausea and sedation score.