Pharmacological Study Of Ethanolic Extract Mangifera Indica Of Leaves And Bark for Their Diuretics Activities

Abstract

Diuretics, substances that promote diuresis and increase the excretion of urine, have long been integral to the treatment of various medical conditions, including hypertension and edema. Natural diuretic agents, derived from plant sources, have garnered attention as potential alternatives to synthetic drugs due to their perceived safety and efficacy. One such botanical resource, Mangifera indica (commonly known as the mango tree), has demonstrated an array of pharmacological properties. This study investigates the diuretic potential of ethanolic extracts obtained from Mangifera indica leaves and bark, shedding light on their traditional medicinal uses. Ethanol was used to extract bioactive compounds from the leaves and bark of Mangifera indica. The diuretic activity of these extracts was evaluated using a well-established animal model. The study compared the diuretic effects of leaf and bark extracts to ascertain potential differences in efficacy. Furthermore, potential mechanisms underlying the observed diuretic effects were explored. The findings reveal significant diuretic activity in both leaf and bark extracts, with notable variations between the two. Comparative analysis indicates that leaf extracts exhibit more pronounced diuretic effects, potentially linked to their rich flavonoid and phenolic content. Further investigations suggest a combination of renal and gastrointestinal mechanisms contributing to the observed diuretic activity.