Phytochemical and Pharmacological Evaluation of Cucumis melo Var. momordica (Roxb.) Linn for anti-anxiety activity

Abstract

This research aimed to explore the phytochemical composition and pharmacological potential of Cucumis melo Var. momordica (Roxb.) Linn as a natural remedy for anxiety disordersWe employed advanced analytical techniques, including chromatography and spectroscopy, to identify and quantify the phytochemical constituents of Cucumis melo Var. momordica. The anti-anxiety activity was assessed using established behavioral paradigms and biochemical assays in animal models. Neurobiological mechanisms were elucidated through neurotransmitter profiling and neural circuitry analysis. Safety and tolerability were evaluated to determine its suitability for therapeutic use.Our findings revealed a diverse phytochemical profile in Cucumis melo Var. momordica, including triterpenoids, flavonoids, alkaloids, and polypeptides. The plant extract demonstrated significant anti-anxiety effects, as evidenced by reduced anxiety-related behaviors in animal models. Neurobiological investigations suggested modulation of neurotransmitter systems and neural pathways associated with anxiety regulation. Importantly, the plant extract exhibited a favorable safety profile with minimal adverse effects.Cucumis melo Var. momordica shows promise as a natural anxiolytic agent, with its phytochemical constituents exerting anti-anxiety effects through modulation of neurobiological pathways. These findings provide valuable insights into the potential therapeutic use of bitter melon in managing anxiety disorders and offer a foundation for further research and development of botanical interventions for anxiety management.