Antidiabetic effect of Murraya koenigii Seeds; petroleum ether extract in alloxan induced diabetic albino rats
Keywords:
Diabetes mellitus, Murraya koenigii seeds, Glibenclamide, serum cholesterol, Petroleum ether extract, Fasting blood sugar (FBS).Abstract
The study of plants having Antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment. The present study was aimed to evaluate the antidiabetic effect of Murraya koenigii seeds with petroleum ether extract in alloxan - induced diabetic albino wistar rat’s model. Healthy wistar albino rats weighing 150- 250 grams were grouped into 5 equal groups taking 6 rats in each. Group A as normal control, Group B was given with standard drug (Glibenclamide 10mg/kg) suspension, Group C as diabetic control, received alloxan after overnight fasting. Group D & E was received alloxan with Murraya koenigii seeds petroleum ether extract suspension at a dose of 200 & 400 mg/kg orally respectively for 28 days & the Murraya koenigii seeds with petroleum ether extract effect on blood sugar was measured at regular intervals. At the end of this research study blood samples were collected from all rats on 0 day (initial), on day 7th, 14th, 21st, 28th of given test drug Murraya koenigii seeds with petroleum ether extract treatment for biochemical estimation of blood sugar with glucometer & the FBS values were observed. This present research study revealed that Murraya koenigii seeds with petroleum ether extract has antidiabetic effect against alloxan induced diabetic albino rats on i.p. alloxan injection at 130 mg/kg & confirms that on i.p. alloxan injection causes a significant raise in fasting blood sugar (FBS) in untreated albino rats when compared to B, D and E group. Treatment of diabetic rats with Murraya koenigii seeds with petroleum ether extract for 28 days caused a dose dependent fall in FBS levels. Glibenclamide treated diabetic rats also showed a significant fall in FBS levels after 28 days of treatment. It is concluded that Murraya koenigii seeds with petroleum ether extract has shown significant antidiabetic effect at a dose of 200 & 400 mg/kg body weight in alloxan induced diabetic albino rats.
