Evaluation Of Anti-Depressant Behaviour Of Alcoholic Extract Of Tectona grandis Linn.On Rats

Abstract

Depression is a prevalent and debilitating mental disorder affecting millions of individuals worldwide. While pharmaceutical drugs have been the primary treatment for depression, there is a growing interest in exploring natural remedies, including plant-based extracts. Tectona grandis Linn., commonly known as teak, is a tropical tree with a history of traditional medicinal use. This study aimed to investigate the potential antidepressant effects of the alcoholic extract of Tectona grandis Linn. on a rat model. In this experimental study, adult male Wistar rats were subjected to behavioral tests to induce depressive-like behavior, including the forced swim test (FST) and tail suspension test (TST). The rats were then administered varying doses of the alcoholic extract of Tectona grandis Linn. orally for a specified period. The animals were subsequently re-evaluated using the same behavioral tests. The results were compared to a control group treated with a placebo. The findings of this study demonstrated that the alcoholic extract of Tectona grandis Linn. exhibited significant antidepressant-like effects in the rat model. Rats treated with the extract displayed reduced immobility time in both the FST and TST, indicative of improved mood and decreased depressive-like behaviour compared to the control group. The dose-dependent response suggested that higher doses of the extract were associated with more pronounced antidepressant effects .This research provides preliminary evidence supporting the potential antidepressant properties of the alcoholic extract of Tectona grandis Linn. on a rat model. Further studies are warranted to elucidate the underlying mechanisms of action and to evaluate its safety and efficacy in humans. If confirmed, Tectona grandis Linn. may hold promise as a natural remedy for depression, offering an alternative or complementary approach to conventional antidepressant medications.