Design, synthesis and evaluation of Delayed Release Microspheres of Greek pitch containing ACE (Angiotensin Converting Enzyme) inhibitor drug

Abstract

In this study, sustained-release Captopril Microspheres were prepared successfully using the solvent evaporation method. It may be concluded that Captopril microspheres would be a promising drug delivery system for oral administration of Captopril to sustain the drug release up to 12 h. The formulation was found to be efficient with good recovery yield, percentage drug entrapment. FT-IR studies did not reveal any significant drug interactions. Captopril microspheres are promising pharmaceutical dosage forms by providing sustained-release drug delivery systems and avoiding the dose related side effects in the entire physiological region. Among the different formulations, microspheres containing F-5 was found to be better as it has higher drug release of 89.83 ± 0.21 % at 12th hour. The diffusion of F5 formulation follows Zero order kinetics fit into the Korsemeyer- Peppa’s model and follows non-Fickian, Formulating Captopril microspheres (F5) was successfully achieved.