Preparation and In vitro Evaluation of Cinnarizine Nanosuspension for Enhancement of Solubility and Dissolution Rate

Abstract

One of the most serious issues with poorly soluble class II medicines is their limited bioavailability. Formulation as nanosuspension is an appealing and promising solution to these difficulties, Cinnarizine is an oral medication used to treat the symptoms of vestibular disorders, such as tinnitus, nausea and vomiting associated with Meniere's disease, this work aimed to formulate and evaluate CNZ nanosuspensions for enhancement the solubility and dissolution rate.

The formulas (F1-F76) were prepared using solvent evaporation technique.

The formulas obtained were assessed for particle size and polydispersity index. After that, entrapment efficiency of some selected formulas was estimated, Particles morphology was investigated by SEM, the crystal form of CNZ was determined using PXRD and its compatibility with components was evaluated by FTIR. In Vitro dissolution research was conducted for the best formula and compared with blank formula, the optimized formula was F62, and it had 189.2 nm particle diameter and 0.213 PDI, with entrapment efficiency 93.63%.